The sermon "Driven to the Streams" by Nick Fain focuses on Psalm 42, where the psalmist expresses deep longing for God's presence. Through sorrow and spiritual panting, believers can draw closer to God and find hope in His promises. The power of song in times of sorrow is highlighted, encouraging believers to find comfort and praise through music. Fain emphasizes the promise of God's presence and comfort, inviting listeners to come and drink from the rivers of living water offered by Jesus.